Determination of hippuric acid in urine by GC/MS. In vivo metabolism of toluene to hippuric acid on toluene poisoning.
نویسندگان
چکیده
منابع مشابه
Urinary hippuric acid concentration after occupational exposure to toluene.
The results of industrial investigations have shown a correlation between the rate of hippuric acid excretion in a single urine sample collected after daily occupational exposure and the amount of toluene absorbed. The rate of hippuric acid excretion and the average concentration of toluene vapour during exposure time were also related. The quantitative range of the test has been limited to amo...
متن کاملToxicokinetics of toluene and urinary excretion of hippuric acid after human exposure to 2H8-toluene.
Nine male volunteers were exposed to 2H8-toluene (200 mg/m3 for two hours during a workload of 50 W) via inspiratory air with the aid of a breathing valve and mouthpiece. Labelled toluene was used to differentiate between hippuric acid originating from exposure to toluene and hippuric acid normally excreted in urine. The total uptake of toluene was 2.2 (standard deviation (SD) 0.2) mmol, or 50%...
متن کاملEvaluation of Toluene Exposure in Workers at Industrial Area of Sidoarjo, Indonesia by Measurement of Urinary Hippuric Acid
Background: Toluene is a harmful substance still being used as a solvent and catalyst in many industries that can increase the level of urinary hippuric acid (UHA). This study was designed to examine the level of toluene and UHA among workers of industrial site in seven companies in Sidoarjo, Indonesia and to analyze the risk factors for abnormal UHA. Methods: This study was an analytical cross...
متن کاملColorimetric determination of hippuric acid in urine and liver homogenate.
To a dried extract Containing hippuric acid (HA), 1.0 mL of acetic anhydride and 2.0 mL of 0.5% p-dlmethyiamlnobenzaldehyde (DAB) solution In pyridine were added, and the solution was kept at 40 O C for 1 h after thorough mlxing. The absorbance was then determlned at 458 nm agalnst a blank containing acetic anhydride, DAB, and pyridine. This method was in good agreement with Beer’s law within 1...
متن کاملDirect colorimetric determination of hippuric acid in urine.
In 1963 Umberger and Fiorese (1) introduced a colorimetric method for HA,1 based on the color reaction of HA, dissolved in anhydrous pyridine, with BSC. Therefore, for applying their method to determine HA in urine, HA must first be extracted from the urine. We found that HA dissolved in water-pyridine (1:1, by vol) produces a red-orange color when BSC is added at room temperature. The absorpti...
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ژورنال
عنوان ژورنال: Journal of the Mass Spectrometry Society of Japan
سال: 1990
ISSN: 1340-8097,1880-4225
DOI: 10.5702/massspec.38.87